Just as Didyma was the holy site for the nearby city of Miletos, so too was Labranda the holy site (of the God Zeus) for the city of Mylasa. The Carian people built a road between Mylasa and Labranda.

The oldest ruins are from BC 600 but most of the present buildings were built in BC 377-344 by the King Mausolos and is brother Idreus. These buildings have withstood many earthquakes. The city was a major center of worship for many centuries and was also famous for the sweetness of its fresh water.